Every Disease.
One Card.
The human disease database — 22,560 diseases integrated from 78 curated sources with gene associations, drugs, variations, phenotypes, and pathways.
How MalaCards Works for You
From scattered disease data to actionable insight in four steps.
78 Sources, One Disease Card
MalaCards automatically integrates gene-disease associations, mutations, phenotypes, pathways, drugs, and more from 78 curated and computed sources into a single, comprehensive disease card.
- → Gene-disease associations scored across 8 evidence sources (OMIM, ClinVar, Orphanet, and more)
- → AI-supported disease summaries distill key clinical and biological insights
- → Quarterly updates keep every card current with the latest research
Find Any Disease, Instantly
Elasticsearch-powered search with stemming and boolean operators takes you directly to the disease you need. Browse by category, search within a card, or explore the full A-Z disease index.
- → Advanced search across disease names, aliases, genes, pathways, and more
- → Browse by category: cancer, genetic, rare, neuronal, metabolic, and more
- → In-card search navigates within any section of a disease card
16 Sections of Deep Disease Data
Every disease card is a complete research dossier with 16 richly annotated sections — from associated genes and drugs to variations, expression data, and pathway analysis.
- → Associated genes with elite (manually curated) and text-mined evidence
- → Drugs, clinical trials, and therapeutic approaches from DrugBank, PharmGKB, and ClinicalTrials.gov
- → Variations from ClinVar, COSMIC, and UniProtKB with structural variant data
- → Related disorders via GeneAnalytics set analysis and comorbidity networks
Your Data, Your Way
Access MalaCards freely for academic research, or license the full dataset for commercial and enterprise use.
- → Free access for non-profit academic institutions and hospitals
- → Commercial data licensing for pharma, biotech, and AI companies
- → Need gene-level data? Explore the GeneCards Knowledge Graph for full data licensing
Inside a Disease Card
Every disease card is a complete research dossier — Ovarian Cancer alone connects to 1,161 genes, 692 drugs, 1,801 pathways, 10,692 ClinVar variations, and 3,383 clinical trials.
The GeneCards Suite
MalaCards is part of a connected ecosystem of biomedical knowledgebases.
The most comprehensive human gene database — 443K+ genes integrated from 200+ sources with interactive visualization and AI summaries.
HUMAN PATHWAY DATABASEUnified human biological pathways. Consolidates overlapping pathways from multiple sources into SuperPaths.
REGULATORY ELEMENTSGenome-wide integration of enhancers and their inferred target genes, with confidence scoring.
GENE SET ANALYSISTranslate gene lists into biological insights with enrichment analysis across pathways, diseases, tissues, and compounds.
VARIANT PRIORITIZATIONPrioritize genomic variants by phenotype, leveraging the GeneCards knowledgebase to rank candidates for clinical and research use.
Licensing
Free for academic research. Flexible licensing for commercial use.
Free Access
Academic & Clinical
- ✓ Non-profit academic institutions
- ✓ Hospital clinicians
- ✓ Individual researchers
- ✓ Full access to all disease cards
Commercial License
Enterprise & Industry
- ✓ Pharmaceutical companies
- ✓ Biotech & diagnostics
- ✓ AI & data companies
- ✓ Custom integration support
Ready to Accelerate Your Research?
Free for academic institutions and hospital clinicians.